Drug Interactions Chart
An abbreviated, at-a-glance guide to HIV drug interactions
compiled by Enid Vázquez
|
|
|
Please see the drug’s page for details, or refer to the manufacturer’s package insert for a full comprehensive list of potential drug interactions. Also, make your pharmacist and health care providers aware of any drug that you add. Some interactions are more serious than others; some drugs may only require a dose adjustment, while others may either render the drug completely ineffective, or worse, lead to a potentially fatal reaction. Discuss any changes, however minor, with your healthcare providers, including your pharmacist, since small reactions may become serious. Look up your drugs with “Check my meds” at www.aidsmeds.com, which lists the effect of food as well as interactions for medications. The University of Liverpool also has an interactive database that allows you to look up antiretroviral drug interactions and has PDF charts of interactions between antiretrovirals and other drugs. Remember, brand names are usually capitalized, while generic names are not. Visit www.hiv-druginteractions.org.
|
Nucleoside analogs (also called “nucleoside reverse transcriptase inhibitors,” or NRTIs, or nukes)
|
| Potential drug class interactions. |
None |
| Combivir |
See Epivir and Retrovir. Do not take Retrovir or Epivir while taking Combivir since these medications are already in Combivir. |
| Emtriva (emtricitabine, FTC) |
No significant drug interactions observed in clinical trials. |
Epivir
(lamivudine, 3TC) |
See Epivir and Ziagen. Do not take Epivir or Ziagen while taking Epzicom since these medications are already in Epzicom. |
| Hivid (zalcitabine, ddC) |
Antabuse, antacids containing magnesium or aluminum, Benemid, certain chemotherapy agents, Chloromycetin, dapsone, Dilantin, Epivir, Flagyl, Foscavir, Fungizone, hydralazine, isoniazid, Maalox, Macrodantin/Macrobid, pentamidine, ribavirin, Tagamet, Videx, and Zerit. |
| Retrovir (zidovudine or ZDV, AZT) |
Amphotericin B, Benemid, Biaxin, Cytovene, dapsone, Depakote, Dilantin, doxorubicin, flucytosine, ganciclovir, hydroxyurea, interferon-alpha, Mycobutin, pentamidine, Rebetol, rifampin, sulfadiazine, Valcyte, Vitrasert, and Zerit. |
| Trizivir (Epivir, Retrovir, and Ziagen) |
See Epivir, Retrovir, and Ziagen. Do not take Retrovir, Epivir or Ziagen while taking Trizivir, since these medications are already in Trizivir. |
| Truvada (Viread and Emtriva) |
See Emtriva and Viread. Do not take Emtriva or Viread while taking Truvada, since these medications are already in Truvada. |
| Videx & Videx EC (didanosine, ddI) |
Alcohol, Cytovene, dapsone, HIV protease inhibitors, Hivid, hydroxyurea, methadone, NebuPent, Nizoral, Rescriptor, Retrovir, ribavirin, Sporanox, Tagamet, Viread, and Zerit. |
| Viread (tenofovir disoproxil fumarate, TDF) |
Kaletra, Norvir, Reyataz, Videx and Videx-EC. |
| Zerit (stavudine, d4T) |
Cytovene, dapsone, Foscavir, Fungizone, Hivid, pentamidine, Retrovir, Valcyte, Videx and Videx-EC, and Vitrasert. |
| Ziagen (abacavir sulfate, ABC) |
Alcohol. |
|
Non-nucleoside analogs (also called “non-nucleoside reverse transcriptase inhibitors,” or NNRTIs, or non-nukes)
|
| Potential drug class interactions |
HIV protease inhibitors; methadone. |
| Rescriptor (delavirdine) |
Adalat, Agenerase, certain amphetamines and antiarrhythmic drugs, Biaxin, birth control pills, Cafergot, carbamazepine (Tegretol and others), Cialis, Coumadin, Crixivan, dapsone, Dilantin, Fortovase, Halcion, immunosuppressants, Invirase, Kaletra, Levitra, Lexiva, methadone, Methergine, Mevacor, Mycobutin, Norvasc, Norvir, phenobarbital, pimozide, Plendil, Procardia, Propulsid, quinidine, rifampin, Reyataz, St. John’s wort, Viagra, Viracept, Versed, Wigraine, Xanax, and Zocor. |
| Rescriptor (delavirdine, DLV) |
Biaxin, birth control pills, Cafergot, carbamazepine (Tegretol and others), Coumadin, Crixivan, Dilantin, Halcion, Fortovase, Invirase, Kaletra, Lexiva, methadone, Methergine, Mycobutin, Norvir, Reyataz, rifampin, Phenobarbital, Sporanox, St. John’s wort, Vfend, Versed, and Wigraine. |
| Sustiva (efavirenz, EFV) |
Birth control pills, HIV protease inhibitors, methadone, prednisone, rifabutin, rifampin, and St. John’s wort. |
| Protease inhibitors (PIs) |
| Potential drug class interactions |
Cardiac medications, cholesterol medication; migraine medications; erectile dysfunction drugs; sedatives; tuberculosis drugs. |
| Agenerase (amprenavir) |
Birth control pills, Agenerase, antiarrhythmics, antibiotics, anticoagulants, antidepressants, antifungals, blood pressure medications, Cafergot, cholesterol medications, Cialis, D.H.E. 45, Halcion, drugs for heartburn or acid reflux, Hismanol, immunosuppresants, Lescol, Levitra, Lipitor, Methergine, Mevacor, Pravachol, Rescriptor, rifampin, Rythmol, sedatives, steroids, drugs for seizures, Seldane, St. John’s wort, Tambocor, Versed, Viagra, Viracept, vitamin E, Wigraine, and Zocor. |
| Aptivus (tipranavir) |
Agenerase, Fortovase, and Kaletra (and probably all other HIV protease inhibitors). See also Norvir. |
| Crixivan (indinavir sulfate) |
Cafergot, Cialis, D.H.E. 45, garlic supplements, Halcion, Hismanol, Lipitor, Lescol, Levitra, Methergine, Mevacor, Mycobutin, Nizoral, pimozide, Pravachol, Rescriptor, Reyataz, rifampin, Rythmol, Seldane, Sporanax, St. John’s wort, Sustiva, Tambocor, Versed, Viagra, Viramune, Wigraine, and Zocor. |
| Fortovase (saquinavir soft-gel) |
Carbamazepine (Tegretol and others), Tambocor, Rythmol, Versed, Halcion, Hismanol, Seldane, rifampin, Cafergot, Wigraine, Methergine, D.H.E. 45, garlic supplements, St. John’s wort, Zocor, Mevacor, Lipitor, Lescol, Pravachol, Rifampin, Crixivan, Norvir, Viracept, Sustiva, Viramune, Decadron, Dilantin, Phenobarbital, Rescriptor, calcium channel blockers, clindamycin, dapsone, quinidine, Viagra, Cialis, and Levitra. |
| Invirase (saquinavir) |
Birth control pills, Cafergot, Cialis, Crixivan, D.H.E. 45, garlic supplements, Halcion, Hismanol, Kaletra, Lipitor, Lescol, Levitra, Methergine, Mevacor, Mycobutin, Nizoral, Norvir, Pravachol, rifampin, Rescriptor, Rythmol, Seldane, St. John’s wort, Sporonox, Sustiva, Tambocor, Viracept, Viagra, Viramune, Versed, Wigraine, and Zocor. |
| Kaletra (lopinavir/ritonavir) |
Antabuse, Biaxin, birth control pills, Cafergot, carbamazepine (Tegretol and others), Cialis, Coumadin, D.H.E. 45, Flagyl, garlic supplements, Halcion, Hismanol, Kaletra, Lipitor, Lescol, Levitra, Lexiva, Mepron, methadone, Methergine, Mevacor, Mycobutin, phenobarbital, phenytoin (Dilantin and others), Pravachol, rifampin, Retrovir, Seldane, Sporanox, St. John’s wort, Sustiva, steroids (especially Decadron), transplant medicines, Versed, Viagra, Videx, Viramune, Wigraine, Ziagen, and Zocor. |
| Lexiva (fos-amprenavir calcium) |
Antabuse, Cafergot, certain calcium channel blockers, Cialis, D.H.E. 45, Flagyl, Halcion, Hismanol, Kaletra, Lipitor, Lescol, Levitra, Lexiva, Mevacor, Pravachol, Rythmol, Methergine, rifampin, St. John’s wort, Sustiva, Tambocor, Viagra, Versed, Wigraine, and Zocor. |
| Norvir (ritonavir) |
See the manufacturer package insert for the most complete list. Alcohol, Antabuse, Biaxin, birth control pills, Cafergot, Cialis, Flagyl, D.H.E. 45, Ecstasy, garlic supplements, GHB, Halcion, Hismanol, Lescol, Levitra, Lipitor, Methergine, Mevacor, Pravachol, rifampin, Rythmol, Seldane, St. John’s wort, Tambocor, tobacco, Versed, Viagra, Wigraine, and Zocor. |
| Reyataz (atazanavir sulfate) |
Aciphex (or any proton-pump inhibitor), Cialis, Cafergot, D.H.E. 45, Fortovase, garlic supplements, Halcion, Hismanol, Lescol, Levitra, Lipitor, Methergine, Mevacor, Mylanta, Nexium, Prilosec-OTC, Pravachol, Prevacid, rifabutin, rifampin, Rythmol, Seldane, St. John’s wort, Sustiva, Tambocor, Versed, Videx and Videx-EC, Viagra, Viread, Wigraine, and Zocor. |
| Viracept (nelfinavir) |
Cafergot, carbamazepine (Tegretol and others), Cialis, Cordarone, Crixivan, D.H.E. 45, Fortovase, garlic supplements, Halcion, Hismanol, Lescol, Levitra, Lipitor, Methergine, Mevacor, Mycobutin, phenobarbital, phenytoin, Pravachol, rifampin, Rythmol, Seldane, St. John’s wort, Tambocor, Versed, Viagra, Wigraine, and Zocor. |
| Fusion inhibitor |
| Fuzeon (T-20, enfuvirtide) |
None reported. |
|
|
| |
|
