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AIDS Dissidents and Denialists

Something went wrong in South Africa this spring. Apparently President Thabo Mbeki, being a responsible political leader in the new 21st century, did what we might expect a responsible 21st century political leader to do: he went online to learn as much as possible about the horrible epidemic that’s currently wiping out large portions of South Africa’s population. And apparently he found some information that disputed the widely-accepted causal link between HIV and AIDS, as well as some scary information about the toxicity of AZT, an expensive medication he’s been urged to supply. The information he found led him to contact Western scientists such as Dr. Peter Duesberg and Dr. David Rasnick, longtime opponents of the commonly accepted theory that HIV is the virus that causes AIDS. Contacting “dissident” Western scientists, and eventually including them in panel discussions concerning the cause of AIDS, caused many other Western scientists to cry foul—what is he doing? doesn’t he know better?—and even propose boycotts of the World AIDS Conference being held in July in South Africa.

I’ve never questioned the causal link between HIV and AIDS, and didn’t even know that anyone still did. So, asked to write an article on the scuffle and knowing very little about Dr. Peter Duesberg and Dr. David Rasnick, I did exactly what good President Mbeki did—I hopped on the ol’ Internet to see what I could find.

What I found made me very, very glad that I am not responsible for coordinating health services and AIDS prevention strategies in South Africa.

There’s more Internet malarkey surrounding HIV, AIDS, recreational drugs and sex, Koch’s Postulates, polio vaccines, and genocidal government conspiracies than I ever thought possible. Some of it is blatant sex-and-drug phobic nonsense, like the “AIDSGate” website run by a thoroughly whacked-out Oregonian who spouts “scientific” data like, “Every single homosexual diagnosed with AIDS has also been a drug user…” and “clean” homosexuals do not get AIDS.” (He also helped start the horrible “Up With People” group back in the ’60s—a hanging crime itself, in my opinion).

But some of it…well, it sure does read well. Gee, I didn’t know there was a dispute as to whether HIV was ever actually isolated and grown in the lab. I didn’t know polio vaccine was made from monkey kidneys. AZT was originally a potential cancer treatment that proved too toxic for common use? Are NIAID and the CDC, my reliable Hotline sources of HIV and AIDS information, really in league with the CIA? I mean, they are government agencies. The U.S. government does have a pretty checkered foreign policy record.

Ahhh! It’s getting deep! Drag me out now, before I’m covered!

Given disparate information, cultural differences in policy-making, and perhaps a healthy dose of mistrust for pharmaceutical companies, I don’t blame President Mbeki for his cautions. Open debate among disagreeing scientists makes a lot of sense in a country that has recently fought bitter battles for democratic self-rule, freedom of speech, and an end to decades of apartheid. I’m also not going to fault him for seeking second opinions before giving South Africa’s pregnant women potentially toxic drugs they can’t afford. However, we can take a hard look at the most frequently debated “dissident” arguments, and see why the majority of the scientific world believes that the HIV-causes-AIDS theory holds water.

Argument 1. In the U.S. and Europe, AIDS is caused by multiple sex partners and heavy use of recreational drugs. In Africa, malnutrition and diseases that have always existed in Africa cause AIDS. HIV is a harmless “passenger” virus and doesn’t cause AIDS.

We all know this one’s ridiculous, but let’s take it right from the National Institute of Allergy and Infectious Disease (NIAID):

“…in a prospectively studied cohort in Vancouver, 715 homosexual men were followed for a median of 8.6 years. Among 365 HIV positive individuals, 136 developed AIDS. No AIDS-defining illnesses occurred among 350 seronegative [HIV negative] men despite the fact that these men reported appreciable use of inhalable nitrites (“poppers”) and other recreational drugs, and frequent receptive anal intercourse.”

As for Africa:

“The diseases that have come to be associated with AIDS in Africa—such as wasting syndrome, diarrheal diseases and TB [tuberculosis]—have long been severe burdens there. However high rates of mortality, formerly confined to the elderly and malnourished, are now common among HIV-infected young and middle-aged people.

“In a recent study in rural Uganda, adolescents and young adults testing positive for HIV antibodies were 60 times more likely to die during the subsequent two-year observation period than otherwise similar persons who tested negative. In a study in Zaire, infants with HIV infection had an 11-fold increased risk of death from diarrhea compared with uninfected children. Elsewhere in Africa findings are similar.”

Argument 2. The toxic effects of AZT and other anti-HIV medications cause AIDS, not the harmless “passenger” virus HIV.

Theories that AZT and other anti-HIV medications themselves cause AIDS are easily dismissed when one recalls all the nice people who died of AIDS before AZT became available in the U.S. and Western Europe in 1987, and all the nice people who are dying globally right now because they will never be able to afford expensive drugs like AZT. However, let’s consult the NIAID Fact Sheet:

“Placebo-controlled trials have found that AZT and related anti-HIV drugs can benefit patients by prolonging, for up to a year or two, the onset of new AIDS-related illnesses in HIV-infected individuals. Significantly, long-term follow-up of these trials, although not showing prolonged benefit of AZT, has never indicated that the drug increases disease progression or mortality. The lack of excess AIDS cases and death in the AZT arms of these trials effectively rebuts the argument that AZT causes AIDS.

“In addition, many individuals who have never taken AZT or related drugs have developed AIDS, including people in the United States prior to the availability of AZT, and in Africa today where very few people receive AZT.”

Argument 3. There are people with AIDS who don’t have HIV, so HIV can’t be the cause of AIDS.

Nicely summarized by Dr. Steven B. Harris, author of “The AIDS Heresies: A Case Study in Skepticism Taken Too Far”:

“Previous to the epidemic of AIDS, of course, people did die of immune failure with low T-lymphocyte counts (including low CD4+ counts) for other reasons, and they continue to do so now…cancer, malnutrition, tuberculosis, radiation, chemotherapy, etc. These people do not have AIDS, because the historical epidemic of AIDS consisted of people with no T-lymphocytes, and yet no known reason for it.

“So let us simply collect all the people we can find with CD4+ counts remaining below 200 (for a few months) without known reason, and test them for HIV. When we do, we find that essentially all are HIV infected, and any who are not do not look at all like typical AIDS patients…Thus, at this point we have no evidence yet to directly contradict the simple theory that HIV causes 100% of our conservatively defined “AIDS.” AIDS skeptics will need different definitions in order to find HIV-free AIDS.”

(I sure do like Dr. Steven B. Harris. I also sure do like the fact that I found his terrific document via the previously cited nutty Oregonian’s “AIDSGate” website, located at www.aliveandwell-eugene.dreamhost.com/aidsgate. The nutty one swears he’s never received a single piece of e-mail disagreeing with any of his statements. Feel free to drop him a line—after all, he is “Up With People”!).

Argument 4. There are people with HIV who don’t have AIDS, so HIV can’t be the cause of AIDS.

It can take years, friends. Longer than we originally thought. And hey, maybe one day we will discover that some people with HIV never develop AIDS—happy news. Until that point, however, we need to realize that 20 years is not a very long time in the life of a complicated disease. We don’t have all the answers yet, but we do have to use what we know.

Argument 5. If AIDS was caused by just one thing, everyone with AIDS would get sick in the same way, in the same amount of time. AIDS behaves differently in different populations, so AIDS must be caused by lots of different things instead of by HIV.

HIV doesn’t cause the diseases associated with AIDS. People with AIDS get funky illnesses because their immune systems are mortally compromised, and people with compromised immune systems will get sick with whatever is floating around them. Different pathogens (disease-causing agents) lurk in different regions and communities, which explains why PWAs in Thailand may become ill with diseases not found in Sturgis, South Dakota, and vice versa. Opportunistic infections vary even by gender and age, due to differences in exposure to various pathogens.

Argument 6. HIV doesn’t fulfill Koch’s Postulates for an infectious disease, so it can’t cause AIDS.

Duesberg’s favorite, refuted several times over the course of AIDS history. Robert Koch discovered anthrax bacillus late in the 19th century and developed the standard determinants for the cause of any epidemic infectious disease.

Postulate #1: Epidemiological Association—Suspected cause of disease must be strongly associated with the disease.

HIV Fulfills Postulate: Antibodies to our RNA from HIV is found in the vast majority of persons with AIDS. Lack of HIV antibodies in less than 5% of cases fulfilling other criteria for AIDS (no other reason for immune system collapse) has been largely attributed to the insensitivity of early tests.

Postulate #2: Isolation—Suspected pathogen must be isolated and propagated outside the host organism.

HIV Fulfills Postulate: HIV has been cultivated in human T-lymphocytes, and cultured cell lines have been grown. (Dr. Duesberg himself agrees!)

Postulate #3: Transmission—Transferring suspected disease agent to uninfected host causes disease in new host.

HIV Fulfills Postulate: Most easily illustrated via the case of three lab technicians accidentally infected with HIV-1 through needle sticks. All three developed antibodies to HIV and experienced marked CD4+ cell depletion and/or opportunistic PCP (Pneumocystis carinii pneumonia) within five years.

There will always be people who will argue over the exact phrasing of Koch’s Postulates, which have been modified over the years due to new technology and knowledge of infectious diseases. Defenders of HIV will continue to argue that other diseases—typhoid fever, leprosy, and tuberculosis—fail to meet strict Koch causality tests. In the meantime, however, HIV does a fine job arguing its case as the causative agent of AIDS.

Laura Jones is a sexual health activist and teacher, and is also a counselor for the Illinois HIV/AIDS and STD Hotline, operated by Test Positive Aware Network

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