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2004 HIV Drug Guide

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One-on-One with Dr. Peter Piot

 

“On current trends, AIDS will kill tens of millions of people over the next 20 years. But this need not happen. We know prevention works. We know that HIV treatment and care work. The global AIDS response is poised to enter a new era: where leadership and commitment are at long last matched with the resources needed to get on with the job. Investment in AIDS will be repaid a thousand-fold in lives saved and communities held together.”

Executive Director of UNAIDS since its creation in 1995 and Under Secretary-General of the United Nations, Dr. Peter Piot comes from a distinguished academic and scientific career focusing on AIDS, other communicable and sexually transmitted diseases, and women’s health in the developing world.

Using his skills as a scientist, manager and activist, Dr. Piot has challenged world leaders to vision AIDS within the realms of social and economic development as well as human security.

Under his leadership, UNAIDS has become the chief advocate for worldwide action against AIDS, with the global mission of leading, strengthening and supporting an expanded response to the epidemic. It has brought together eight organizations of the United Nations system around a common agenda on AIDS, spearheading UN reform.


Charles Clifton: Why AIDS? Why are you so intimately involved in this global cause? Would you please speak a bit about your background, your interest in AIDS and how/what UNAIDS is all about?

Dr. Peter Piot: Perhaps unusually, the things that I thought were important when I was first starting out as a medical researcher were the unfashionable areas, but which were responsible for a great deal of illness, especially in tropical Africa.

So I was working on women’s health and sexually transmitted diseases (STDs) in the early 1980s, when AIDS first appeared. I had been working in the then Zaire. I vividly recall returning in 1983 to see the wards of the largest hospital filled with both men and women suffering from this new disease. From that moment on, it was clear that there would be a new crisis we had to deal with, but I don’t think anyone could have foreseen just how comprehensively and devastatingly AIDS would spread globally.

In 1994, it was becoming clear that the epidemic was much more than just a health problem, and needed a new kind of coordinated UN (United Nations) response. UNAIDS was created, beginning officially on 1 January 1996, and at that stage was the leading edge of UN reform. We bring together eight co-sponsors in a joint focus on AIDS, ranging from the World Bank to UNICEF and the UN Development Programme. UNAIDS has a fairly small secretariat, with much of our staffing comprising UN country AIDS coordinators in high priority countries around the world. With the secretariat and co-sponsors, we provide global leadership and advocacy, and the world’s information about the state of the epidemic and best practices in response.

CC: Politicising AIDS: There is a lot of noise in the U.S. media about what the Bush administration is and isn’t doing to adequately address the AIDS epidemic and that HIV prevention isn’t being driven by scientifically sound approaches. In addition, AIDS activists from around the world are directing pressure on pharmaceutical companies and governments to do more on the international access to treatment issue and especially in regards to allowing for the production and distribution of generic drugs. However, other than the problems in South Africa and occasionally Brazil, we very seldom hear about where AIDS is on the political agenda in other countries. Can you speak about where is AIDS on the political and social agendas of China, other parts of Africa, the Caribbean and Central America? What are the broad issues as they relate to care and support, and specifically access to antiretrovirals and treatment?

PP: Over the past six years, we have seen more and more governments make AIDS a political priority, breaking down the walls of silence surrounding the epidemic. Today, we see presidents and prime ministers throughout Africa, the Americas, the Caribbean, Asia and Eastern Europe publicly displaying personal commitment to the fight against AIDS. They have recognized that AIDS is not just a health issue; it is fundamental to development, progress and security. Dozens of countries now have national AIDS commissions and strategies in place. In almost 30 countries, presidents or prime ministers head them—an indication of the priority they personally attach to the problem. Of these, 13 countries are in Africa. These are encouraging signs.

In the Caribbean, for example, the region’s Heads of State came together to form the Pan-Caribbean Partnership on HIV/AIDS in February 2001. As part of the Partnership, governments work closely with the international community and civil society to boost national and regional responses to HIV/AIDS.

In Africa, the Heads of State from several countries (including Mali, Nigeria, Rwanda, South Africa and Uganda) have come together to form AIDS Watch Africa. This initiative enables members to alert other Heads of State to the threat AIDS poses to development, and to encourage them to tackle the epidemic.

China appears to be on the brink of an explosive and generalized HIV epidemic if wide scale, effective prevention programs are not implemented very soon. There are already serious HIV epidemics among injecting drug users and sex workers, and HIV is likely to spread to the general population due to high rates of STDs (sexually transmitted diseases), ignorance about HIV, lack of access to condoms and sexual health services, and large-scale internal migration. Official estimates put the number of people living with HIV in China at one million in mid-2002. Extensive HIV infection, of 150,000 people (and possibly many more), has also occurred among blood donors in rural areas of central China. The government has acknowledged the situation and is trying to remedy it. However, there is need for greater openness about the extent of the problem, as well as greater efforts to address it and support those affected. UNAIDS and others are working, for example, in the highly affected Henan Province to increase access to care and support.

Increased access to comprehensive HIV care and support, including antiretroviral medicines and treatment for HIV-related opportunistic infections, is a global priority. As drug prices drop and health systems improve, significant progress is being made in these areas. But treatment and care are not yet reaching the vast majority of people in need.

A new analysis of access to treatment shows that of the six million people in the developing world in need of antiretroviral drug therapy, just 230,000, less than 4% were receiving antiretroviral drugs at the end of 2001. In high-income countries, where an estimated 500,000 people were receiving antiretroviral treatment, 25,000 people died of AIDS in 2001. In Africa, however, where only some 30,000 of the 28.5 million people infected were receiving antiretroviral treatment, AIDS killed 2.2 million people in 2001.

Access to adequate care and treatment is a right, not a privilege. Although real progress has been made in lowering the price of antiretroviral therapy in the developing world, far greater action is needed by both governments and the private sector to ensure that treatment reaches those in greatest need. The cost of treatment must continue to fall, and governments in both the developing world and donor countries must create sustainable funding streams to provide treatment, while strengthening the healthcare infrastructure.

CC: I attended my first International AIDS Conference in Durban nearly three years ago. A week prior to the conference I had the opportunity to visit the townships outside of Capetown and clinics in Durban. I was completely overwhelmed by what I saw and couldn’t imagine any type of substantial response to the sheer numbers facing the country. However, by the time the conference had ended my attitude had completely changed, I had had a chance to visit and talk with people working at the grassroots and community level. Only then did I begin to understand that, yes there is hope. There is life. There is a chance. In your work with non-Western countries, in countries that have been defined in the U.S. as resource-limited, what successes have you witnessed in how people and communities have responded to this epidemic over the last few years?

PP: Despite the fact that the epidemic continues to grow in most regions of the world, we do see some signs of hope where countries have managed to reduce HIV prevalence and/or provide affordable care for people living with HIV/AIDS.

A number of African countries are continuing to register success in fighting the epidemic as a result of increased commitment from governments, businesses and communities. HIV prevalence continues to drop in Uganda—down to 5% at end-2001, compared to 8.3% at end-1999. HIV prevalence is falling among young urban women in Zambia—from 28% to 24% among 15-29 year-old urban women between 1996 and 1999, and from 16% to 12% among rural women ages 15-24.

Cambodia, like Thailand, is showing that the “natural” course of the epidemic can be changed. Strong political commitment and large-scale prevention programs have helped lower adult HIV prevalence from 4% at end 1999, to 2.7% at end 2001 in Cambodia.

By mounting a strong national response, the Polish government has successfully curtailed the epidemic among injecting drug users and prevented it from gaining a foothold in the wider population.

Latin America and the Caribbean show that middle- and low-income countries (where HIV prevalence is still relatively low) can provide treatment and care through the public sector. Eleven countries in Latin America and the Caribbean now have policies and laws that guarantee antiretroviral therapy for their HIV-positive citizens, although this does not mean all in need receive treatment yet. Across the region, about 170,000 people now receive antiretroviral treatment, of which 100,000 are in Brazil.

The key to cracking this epidemic seems to be a specific combination of community action from the grassroots meeting leadership, not only from governments but also from civil society, religious organizations, women’s and youth groups, and business.

CC: Money. There never seems to be enough. It’s been reported that something like $10 billion is needed annually to address HIV and AIDS in developing countries. How much money is currently being directed towards the Global Fund? Who is at the table supporting the Fund at the corporate, governmental and public level? Who is missing and why? And what can we realistically expect to be accomplished over the next few years?

PP: The Global Fund to Fight AIDS, TB and Malaria has received total pledges over five years of US$2.2 billion, the first $1 billion of which was available in 2002, with a further $650 million becoming available in 2003. In its first two rounds of grants, the Fund committed itself to disbursing $1.5 billion in 2003 and 2004.

The idea behind the Fund is to build an independent global/private partnership to attract, manage and disburse new resources to fight AIDS, TB and malaria. The Fund is not meant to replace current efforts but to raise additional resources from new sources, at the same time as support for current efforts is increased. The Fund’s partners—national governments, multilateral organizations, NGOs (non-government organizations) and the private sector—are equally committed to supporting and assisting the Fund in its operations, and to ensuring that resources flow rapidly to where they are most needed.

To date, governments have been the major contributors to the Global Fund, although there have also been significant contributions from some businesses, foundations, and individuals. The Fund publishes an up-to-date list of the pledges it has received, so is very easy to see where the money is coming from (www.unaids.org).

The Fund has been established very quickly and made its first disbursements in near record time, given the international context in which it is working. The coming year is critical to maintain the Fund’s momentum. It will be the most challenging in attracting new pledges in a period when it is still too early to demonstrate that the current disbursements have made a difference. UNAIDS is working closely with the Fund, in particular to help ensure that developing countries have the right support to make good proposals for funding.

CC: 2004 International AIDS Conference, Thailand. If you were to look into a crystal ball, what would you like to see at that time?

PP: At the Barcelona conference last year, there was for the first time a Leadership Track. I would like to see the leadership efforts at the conference greatly expanded. Heads of state need to be there, together with major decision makers—we’ll know we’re really getting somewhere when finance ministers see that this sort of conference is important. But as well, the conference needs to bring together trade union leaders, women’s leaders, intellectuals and activists—not necessarily just those currently in the AIDS movement.

I’d like to see the conference reflecting a truly scaled-up response from around the world. That means a lot more attention to the politics, economics, and implementation research, which ought to accompany broad-scale AIDS responses.

I hope there will be some good news on vaccines, microbicides, and more effective and simpler treatment regimens. With the twin messages of technological advances and political progress, we would all be given reason for hope.

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